Observe.
Understand.
Relieve.
XIN XIONG · SCIENTIFIC INQUIRY
Computational oncology · Functional genomics · Synthetic biology
I map how cells communicate, then carry the strongest hypotheses back to experimental systems.
SELECTED WORK / 01
Five representative projects across computation and the wet lab. Open each record for the question, method, and current evidence.
01 / COMPUTATIONAL ONCOLOGY
Integrated more than two million single cells across over ten cancer types to investigate conserved signaling hubs, cell communities, and tumor niches, with spatial validation as the next layer of evidence.
02 / FUNCTIONAL GENOMICS
IN PROGRESSMutant design, targeted degradation, immunofluorescence, and live-cell phenotyping distinguish phosphorylation-dependent activity from KEOPS-complex-dependent function.
Read the project record03 / CANCER PLASTICITY
RNA-seqIn a doxycycline-regulated KRAS-mutant pancreatic cancer model, recurrent tumors emerging after KRAS inactivation showed upregulation of EMT-related transcriptional programs, highlighting a candidate mechanism of RAS-independent recurrence.
Read the project record04 / MOBILE GENETIC ELEMENTS
2023 — 2024Combined computational prediction with lifecycle and transfer validation to study how mobile genetic elements cooperate across bacterial genomes.
Read the project record05 / SYNTHETIC BIOLOGY
iGEM 2025Built a modular B. subtilis adhesion scaffold spanning genome editing, SpyTag/SpyCatcher design, protein purification, and material functionalization.
Visit the iGEM projectSELECTED HIGHLIGHTS / 02
A compact view of academic performance, research scale, and training.
Recognized in 2024 and 2025.
GPA 3.89 / 4.0 in Biotechnology.
Across more than ten cancer types.
Computational life science, systems biology, and experimental training.
EXPERIENCE / 03
From microbial genetics to pan-cancer systems biology, with computation and experiments kept in the same loop.
Single-cell integration, signaling networks, conserved cellular hubs, and spatial validation.
dTAG degradation, immunofluorescence, and live-cell phenotyping in medulloblastoma.
Genome editing, modular protein design, purification, and adhesion validation.
Prediction, assay design, and wet-lab validation in Staphylococcus aureus.
CONTINUE / 04
Methods, evidence, notes, and the person behind them.